In the course of study, antihyperglycemic effect of camel milk either as a single treatment or in combination with metformin was investigated in hyperglycemic rabbits. Thirty-five female rabbits were divided into 5 groups with seven rabbits in each group.Group1 rabbits were kept as negative control. Alloxan^® @ 170mg/kg injected intravenously in remaining rabbits for inducing hyperglycemia. Group 2 rabbits were categorized as hyperglycemic positive control, Group 3 rabbits were orally administered metformin (Glucophage^®) @100mg/kg/day, Group 4 animals were orally administered camel milk @40ml/kg/day, and Group 5 animals were orally administered with camel milk @40ml/kg/day and metformin (Glucophage^®) @100mg/kg/day in combination for sixty days. Body weight and fasting blood glucose levels were recorded weekly. Alloxan^® administration reduced body weight, insulin, glucokinase (GCK), total antioxidant capacity (TAC), total protein and albumin level. Fasting blood glucose, serum glucose, total oxidative stress (TOS), kidney function biomarkers, and aminotransferases significantly increased. Use of camel milk and metformin restored body weight, insulin, GCK, TAC, total protein, albumin, and hematological parameters at significant level (P<0.05). Glycemic level, aminotransferases, TOS, kidney function biomarkers were significantly decreased after treatment. Histological observations showed restoration of disrupted histology of liver, kidneys, and pancreas close to normal structure in all treated groups. Use of camel milk either alone or with metformin showed significant potential to restore altered hematobiochemical parameters and cellular architecture in the hyperglycemic rabbit model.