The present study was designed to evaluate the palliative potential of ginkgetin (GK) against polystyrene microplastics (PS-MPs) instigated renal damage in rats. 24 rats were separated into 4 groups i.e., control, PS-MPs-intoxicated (0.01mgkg^-1), PS-MPs (0.01mgkg^-1) and GK (25mgkg^-1) administrated and GK (25mgkg^-1) only treated group. Results of the experiment showed that the activities of anti-oxidant enzymes i.e., glutathione S-transferase (GST), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GSR) & catalase (CAT) were significantly decreased, while the levels of ROS and MDA were increased following PS-MPs treatment. Furthermore, PS-MPs intoxication increased the levels of kidney function markers such as creatinine, urea, NGAL and KIM-1, while a significant reduction was observed in creatinine clearance. Moreover, PS-MPs significantly increased the TNF-α, NF-κB, IL-6, IL-1β levels and COX-2 activity. Furthermore, it reduced the Bcl-2 level, while increasing the levels of Caspase-9, Bax and Caspase-3 and induced histological damages in the renal tissues. However, the treatment of GK significantly regulated the biochemical, renal, inflammatory, apoptotic markers and attenuated the PS-MPs induced histopathological damages due to its reno-protective, anti-apoptotic, anti-oxidant and anti- inflammatory nature.