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Protective Effects of Selenium Against Acrylamide-Induced Hepatotoxicity in Rats
Mehmet Enes Sozen1*, Hasan Basri Savas2 and Gokhan Cuce3

1Alanya Alaaddin Keykubat University, School of Medicine, Department of Histology and Embryology. Antalya, Turkey; 2Mardin Artuklu University, School of Medicine, Department of Medical Biochemistry. Mardin, Turkey; 3Necmettin Erbakan University, Meram School of Medicine, Department of Histology and Embryology. Konya, Turkey
*Corresponding author:


Acrylamide (ACR) is an organic chemical widely consumed worldwide, depending on the diet. ACR has toxic effects on the liver and other organs due to oxidative damage. The research is aimed to determine the effects of Selenium (Se) against ACR toxicity. 32 Wistar albino male rats were divided into Control, ACR, Se, and ACR+Se groups. After slaughter on the 28th day, the blood samples taken from the animals were tested for total oxidant status (TOS) and total antioxidant status (TAS) to assess oxidative stress. The liver tissue sections were evaluated for lymphocyte infiltration, hepatocyte degeneration, sinusoid dilatation, and congestion. IL-6, Bax, and Bcl-2 expression were evaluated with immunohistochemistry. While the ACR group's TOS and oxidative stress index (OSI) values were significantly higher than the control group's, there was no significant difference in the ACR+Se group's TOS and OSI values. The ACR group had a considerably higher histopathological score than the other groups. ACR increased IL-6, and Bax levels and decreased Bcl-2 levels compared to the control, Se, and ACR+Se groups. ACR increased oxidative stress significantly caused toxic effects, inflammation, and cell death in the liver. On the other hand, Se oral supplementation may protect against oxidative stress, toxic effects, inflammation, and cell death induced by ACR in the liver.

To Cite This Article: Sozen ME, Savas HB and Cuce G, 2024. Protective effects of selenium against acrylamide-induced hepatotoxicity in rats. Pak Vet J.


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)