Helminths are widespread infectious agents, causing severe economic and performance losses in all animals, especially donkeys. Strongylus (S.) vulgaris and Fasciola (F.) hepatica are abundantly present in the equines. Their control using herbal is being necessitated because of the resistance of parasites towards routinely used chemicals. In this study, 60 positive animals were divided equally into 4 groups, each having three replicates named A, B, C, and D. Donkeys in groups A, B, and C received 1200, 1000, and 800 mg/kg mixture of 4 plants of family Apiaceae while the group D was kept as non-medicated control. The medication of the animals was done for 4 weeks. fecal, hematological, and hepato-renal function-related serum samples were collected on days 0, 14, and 28 of the experiment to estimate the effects of herbal mixture on fecal egg count reduction, red blood cell counts, white blood cells, hemoglobin, packed cell volume, alanine aminotransferase, aspartate transferase, serum proteins, serum albumins, urea, and creatinine. The donkeys were weighed at the start and end of the trial to estimate the effect of the herbal mixture on weight gain. The results suggested that total helminth, S. vulgaris, and F. hepatica egg counts were significantly (p<0.05) less than the control group. Herbal mixture significantly (p<0.05) improved the red blood cells, packed cell volume, hemoglobin, total proteins, albumins, and weight gains of the donkeys treated with 1200 mg/kg herbal mixture. The results suggested that the herbal mixture from the plants of the family Apiaceae was effective in controlling the helminths and improving hematological and serological parameters.