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Protective Effect of Bajakah Tampala (Spatholobus littoralis Hassk.) on Dexamethasone-Induced Renal Toxicity in Albino Rats
Tata Anfarul Akmal1, Cahya Farah Dina1, Aditya Yudhana1, Faisal Fikri1*, Agus Purnomo2, Salipudin Tasil Maslamama3 and Muhammad Thohawi Elziyad Purnama1,3

1Department of Veterinary Science, Faculty of Health, Medicine, and Life Sciences, Universitas Airlangga, Banyuwangi, Indonesia; 2Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; 3Department of Biology, Graduate School of Natural and Applied Sciences, Eskişehir Osmangazi Üniversitesi, Eskişehir, Türkiye
*Corresponding author:


This study aimed to investigate the efficacy of bajakah tampala (Spatholobus littoralis Hassk.) extract on IL-1 and IL-6 cytokine expression, renal histopathology, and hematological profile in albino rats suffering from dexamethasone-induced renal toxicity. A total of 25 male rats were divided into five groups, each with five replications i.e. (C-) placebo, (C+) animals were injected subcutaneously with 0.1 mg/kg BW of dexamethasone, (T1; T2; T3 groups) animals were injected subcutaneously with 0.1 mg/kg BW of dexamethasone, and administered orally with 200; 300; 400 mg/kg BW of S. littoralis Hassk extract, respectively. A subcutaneous injection of 0.1 mg/kg BW of dexamethasone followed by an oral dose of S. littoralis Hassk extract was administered three times a week consecutively for 30 days. IL-1 and IL-6 expressions were evaluated using immunohistochemical staining, renal histopathology using H&E staining, while the hematological profile was quantified using a hematology analyzer. As a result, comparing the T2 and T3 groups to the C+ group, there was a significant decrease in the expression of IL-1 and IL-6. Meanwhile, the T3 group displayed results similar to the C- group. Based on histological findings, the T2 and T3 groups showed significant improvements when compared with C+ group. Furthermore, the T3 group's study of the hematological profile showed a significant improvement in leukocyte, erythrocyte, platelet, BUN, uric acid and creatinine levels when compared with the C+ group. In conclusion, the administration of 300 mg/kg BW of S. littoralis Hassk extract has the potential to mitigate renal toxicity caused by dexamethasone, as evidenced by improvements in IL-1 and IL-6, renal histology, and hematological profile.

To Cite This Article: Akmal TA, Dina CF, Yudhana A, Fikri F, Purnomo A, Maslamama ST and Purnama MTE, 2024. Protective effect of bajakah tampala (Spatholobus littoralis Hassk.) on dexamethasone-induced renal toxicity in albino rats. Pak Vet J.


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)

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