Paraquat (PQT) is among the most toxic herbicides that possesses the potential to exert deleterious effects on animal and human health. Kaempferide (KMF) is a natural flavanol that manifests profound therapeutic potential. Rats (n=24) were separated into 4 groups i.e., Control, PQT 5 mgkg^-1, PQT 5 mgkg^-1 + KMF 20 mgkg^-1 and KMF 20 mgkg^-1 administered group. After 30 days of treatment, our results revealed that PQT exposure reduced the activities of antioxidant enzymes i.e., glutathione S-transferase (GST), glutathione (GSH), superoxide dismutase (SOD), glutathione reductase (GSR), catalase (CAT), glutathione peroxidase (GPx) and heme oxygenase-1 (HO-1) while increased the levels of malondialdehyde (MDA) and reactive oxygen species (ROS). Furthermore, PQT intoxication reduced the level of renal biomarkers i.e., creatinine clearance, and increased the level of creatinine, urea, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1). In addition to this, it increased the levels of nuclear factor-kappa B (NF-kB), tumor necrosis factor-alpha (TNF-a), interleukin-1beta (IL-1β) and interleukin-6 (IL-6) as well as increased the activity of cyclooxygenase-2 (COX-2).   Furthermore, PQT exposure increased the levels of caspase-9, Bax and caspase-3 while it decreased the levels of Bcl-2. Additionally, histological analysis showed substantial renal tissue damage in PQT intoxicated rats. However, KMF treatment recovered the renal impairments. Therefore, it is proposed that KMF may be used as a nephroprotective agent against PQT-prompted renal toxicity.