PAKISTAN VETERINARY JOURNAL

Pak Vet J, xxxx, xx(x) xxx-xxx

Potential beneficial effects of L-carnitine and allicin on Doxorubicin induced nephrotoxicity in Rats

Adil Aldhahrani¹, Heba I. Ghamry², Ahmed Soliman³, Mohamed Alkafafy⁴, Maram H. Abduljabbar⁵, Ahmed Farag⁶ and Mohamed Aboubakr^7*

¹Clinical Laboratory Sciences Department, Turabah University College, Taif University, 21995, Saudi Arabia. ²Nutrition and Food Science, Department of Biology, College of Science, King Khalid University, P.O. Box 960, Abha, 61421, Saudi Arabia. ³Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, 12211 Giza, Egypt. ⁴Department of Biotechnology, College of Science, Taif University, Taif 21944, Saudi Arabia. ⁵Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, Taif, 21944, Saudi Arabia. ⁶Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt. ⁷Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt.
*Corresponding author: mohamed.aboubakr@fvtm.bu.edu.eg

Abstract

The current study was carried out to find out the potential beneficial effects of L-carnitine (LC) and allicin (ALC) to ameliorate the potential toxic effects of doxorubicin on kidneys. For this purpose, a total of 49 rats were divided in 7 groups (7/each) including a control group, a group treated with ALC (20mg/kg, orally), a group treated with DOX (20mg/kg. intraperitoneal injection), a group receiving ALC and DOX combination, a group receiving LC (100mg/kg/day), a group receiving ALC and DOX combination, and a group receiving ALC, DOX and LC in combination. The DOX induced an increase in creatinine and urea, however a significant decrease in total protein and albumin level was observed along with notable renal tissue damage. In terms of stress and oxidative parameters, DOX led to elevated TNF-α expression, increase in MDA (malondialdehyde), decrease in reduced GSH (glutathione), SOD (superoxide dismutase) and CAT (catalase) levels. However, both ALC and LC, separately or in combination, effectively reduced kidney damage and apoptosis induced by DOX. Hence it is concluded that ALC and/or LC may be beneficial supplements for cancer patients undergoing DOX treatment.

To Cite This Article: Aldhahrani A, Ghamry HI, SolimanA, AlkafafyM, AbduljabbarMH, FaragA and Aboubakr M, 2025. Potential beneficial effects of L-carnitine and allicin on Doxorubicin induced nephrotoxicity in Rats. Pak Vet J. http://dx.doi.org/10.29261/pakvetj/2025.005

Abstract

ISSN 0253-8318 (Print)ISSN 2074-7764 (Online)

ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)