Liver is considered as the most important organ for metabolism, bile production, detoxification, and antioxidant defense in animals and humans. Liver diseases in animals represent major health and economic concerns because of their impact on productivity. Conventional hepatoprotective drugs are effective, but their use is constrained by adverse effects, antimicrobial resistance, and residue concern. These limitations of conventional hepatoprotective drugs make the scientists focus on new alternative treatments. Medicinal plants and their bioactive compounds are considered as the best among all the alternative strategies. The diverse biological activities of botanical compound make them suitable candidates to be used as hepatoprotectives. In this review, we will briefly discuss multiple hepatic diseases and detailed mechanisms of action of botanical compounds for better understandings to formulate new alternative products.

To Cite This Article: Xu J, Sui J, Luo Y, Zhao Q, Bi W, Duan H, Fu Y, Yang Q, Sun J, Dai F, Gu X, Wu Y and Qu W, 2025. The protective and therapeutic effects of herbal medicines on hepatic disorders in animals. Pak Vet J, 45(4): 1491-1502. http://dx.doi.org/10.29261/pakvetj/2025.324