Effects of Minimum and Maximum Doses of Furosemide on
Fractional Shortening Parameter in Echocardiography of the New
Zealand White Rabbit
Roham Vali, Mohammad Nasrollahzadeh Masouleh* and Siamak Mashhady
Rafie1
Department of Radiology; 1Department of Small Animal
Internal Medicine, Faculty of Specialized veterinary Science,
Science and Research Branch, Islamic Azad University, Tehran, Iran
*Corresponding author:
mnmasouleh@srbiau.ac.ir
Abstract
There is no data on the effect of maximum and minimum doses of furosemide on
heart's work performance and amount of fractional shortening (FS) in
echocardiography of rabbit. This study was designed to validate probability of
the mentionable effect. Twenty-four healthy female
New Zealand
white rabbits were divided into four equal groups. Maximum and minimum doses of
furosemide were used for the first and second groups and the injection solution
for the third and fourth groups was sodium chloride 0.9% which had the same
calculated volumes of furosemide for the first two groups, respectively. The
left ventricle FS in statutory times (0, 2, 5, 15, 30 minutes) was determined by
echocardiography. Measurements of Mean±SD, maximum and minimum amounts for FS
values in all groups before injection and in statutory times were calculated.
Statistical analysis revealed non-significant correlation between the means of
FS. The results of this study showed that furosemide can be used as a diuretic
agent for preparing a window approach in abdominal ultrasonography examination
with no harmful effect on cardiac function.