Visual Evoked Potentials to Light Flashes in Captive Rhesus Monkeys: A Study Reflecting Cerebral Cortical Activity and Brain
Maturation
S.A. Solís-Chávez1,2,*,
A. Durand-Rivera3, A. Ibáñez-Contreras1,2,
S.A. Reyes-Pantoja1,2,K. Valderrama1,
Y. Heras-Romero4,5, E. Tena-Betancourt4, A.
Galván-Montaño6, A. Alfaro-Rodríguez3 and B.
Hernández-Godínez1,2
1Centro de Investigación, Proyecto CAMINA, A.C., México City. México.
Calzada de Tlalpan 4430 Col, Toriello Guerra, México
DF, Mexico; 2Unidad de Experimentación Animal. BIOINVERT®.
Biología Integral para Vertebrados, Edo. México, México; 3Laboratorio
de Neuroprotección. Instituto Nacional de Rehabilitación. SSA.
México DF, Mexico; 4Departamento de Etología Fauna Silvestre y Animales de
Laboratorio, Facultad de MedicinaVeterinaria y Zootecnia, UNAM, México DF,
Mexico; 5Departamento de Bioterio. Instituto
Nacional de Neurología y Neurocirugía Manuel Velazco Suarez. S.S.A
México DF, Mexico; 6Dirección de Cirugía Pediátrica. Hospital General Dr Manuel
Gea González S.S.A, México DF,
Mexico *Corresponding author: ibanez.alejandra@hotmail.com
Abstract
Visual evoked potentials (VEPs) are useful
electrophysiological diagnostic tools for evaluating retinal response of the
visual cortex and detecting its functional integrity in humans and animals. To
analyze the VEPs and physiologic response of the visual pathway of a random
population of captive-bred monkeys of the
Macaca mulatta species throughout different physiologic stages after
stimulation with stroboscopic light flashes. Inthis study we used 20 non-human primates (M.
mulatta), 10 males and 10 females, divided into five age-dependant cohorts
of 2 males and 2 females. Two replicable negative waveforms and one positive
were recorded, as reliable indicators of electrical conductivity at specific
anatomical nuclei of the visual pathways.Statistically significant differences were primarily observed in group 1
when compared against the remaining groups for the three evaluated waveforms.
Waveform morphology characteristically presented steady deviations related to
ontogenetic development of the studied population.