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Visual Evoked Potentials to Light Flashes in Captive Rhesus Monkeys: A Study Reflecting Cerebral Cortical Activity and Brain Maturation
S.A. Solís-Chávez1,2,*, A. Durand-Rivera3, A. Ibáñez-Contreras1,2, S.A. Reyes-Pantoja1,2, K. Valderrama1, Y. Heras-Romero4,5, E. Tena-Betancourt4, A. Galván-Montaño6, A. Alfaro-Rodríguez3 and B. Hernández-Godínez1,2
1Centro de Investigación, Proyecto CAMINA, A.C., México City. México. Calzada de Tlalpan 4430 Col, Toriello Guerra, México DF, Mexico; 2Unidad de Experimentación Animal. BIOINVERT®. Biología Integral para Vertebrados, Edo. México, México; 3Laboratorio de Neuroprotección. Instituto Nacional de Rehabilitación. SSA. México DF, Mexico; 4Departamento de Etología Fauna Silvestre y Animales de Laboratorio, Facultad de Medicina   Veterinaria y Zootecnia, UNAM, México DF, Mexico; 5Departamento de Bioterio. Instituto Nacional de Neurología y Neurocirugía Manuel Velazco Suarez. S.S.A México DF, Mexico; 6Dirección de Cirugía Pediátrica. Hospital General Dr Manuel Gea González S.S.A, México DF, Mexico
*Corresponding author:


Visual evoked potentials (VEPs) are useful electrophysiological diagnostic tools for evaluating retinal response of the visual cortex and detecting its functional integrity in humans and animals. To analyze the VEPs and physiologic response of the visual pathway of a random population of captive-bred monkeys of the Macaca mulatta species throughout different physiologic stages after stimulation with stroboscopic light flashes. In this study we used 20 non-human primates (M. mulatta), 10 males and 10 females, divided into five age-dependant cohorts of 2 males and 2 females. Two replicable negative waveforms and one positive were recorded, as reliable indicators of electrical conductivity at specific anatomical nuclei of the visual pathways. Statistically significant differences were primarily observed in group 1 when compared against the remaining groups for the three evaluated waveforms. Waveform morphology characteristically presented steady deviations related to ontogenetic development of the studied population.

Key words: Brain maduration, Latency, Macaca mulatta, Neuronal Maturation, Ontogenetic Development, Visual Cortices, Visual Evoked Potentials (VEP)


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)