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Quorum Sensing Molecules Acyl-Homoserine Lactones and Indole Effect on T4 Bacteriophage Production and Lysis Activity
Muhammad Kamran Taj, Lin Lian Bing, Zhang Qi, Ji Xiu Ling, Imran Taj, Taj Muhammad Hassani, Zohra Samreen, Aslam Mangle and Wei Yunlin*
Kunming University of Science and Technology, Faculty of Life Science and Technology, Yunnan China
*Corresponding author:;


The present study was an effort to look at the effect of quorum sensing molecules which are acyl-homoserine lactones and indole on production and lytic activity of T4 bacteriophage. A predator/prey system model was employed to conduct the experiment. Results obtained during the study showed that acyl-homoserine lactones (AHL), which are essential signaling molecules of quorum sensing in many Gram-negative bacteria, can increase T4 phage production and lysis against Escherichia coli BL21 (DE3) pLysS. In addition, our study showed that indole which can also act as a signaling molecule and is a common diagnostic marker for the identification of E. coli reduced the lysis activity and production of T4 bacteriophage.

Key words: AHL, E coli, Indole, Quorum Sensing, T4 Phage


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)