A 12-year-old, intact male, Labrador Retriever dog was referred to our hospital with a 1-week history of depression and azotemia that had not responded to symptomatic fluid therapy. Based on the history, clinical examination, CBC, serum biochemical analysis, urinalysis, and diagnostic imaging, the dog was tentatively diagnosed with glomerulonephropathy concurrent with a splenic tumor. Following a splenectomy and renal biopsy, renal amyloidosis and hemangioma were confirmed on histopathology. Despite intensive care with intermittent hemodialysis, the dog’s condition deteriorated and died 12 days after admission. This case illustrates that splenic hemangioma can be related to renal amyloidosis.

Key words: Chronic Kidney Disease (CKD), Dog, Hemodialysis, Renal amyloidosis, Splenic hemangioma