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Pulmonary Leucocytoclasitc Necrotizing Vasculitis in a Dog with Uncorrected Tetralogy of Fallot and Peritoneopericardial Diaphragmatic Hernia
Hyun-Ah Park1, Min-Hee Kang1, Dae-Young Kim2 and Hee-Myung Park1*
1Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 143-701, South Korea; 2Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA; *Corresponding author:


A 5-year-old, 5.4 kg, intact female mixed-breed dog presented with acute respiratory distress. Echocardiography showed pulmonary valvular stenosis with narrowing valvular annulus, ventricular septal defect, overriding aorta and the right ventricular hypertrophy. Other concurrent abnormality included sternal deformity, peritoneopericardial diaphragmatic hernia. The dog was diagnosed as a Tetralogy of Fallot. Despite treatments, the dog died 4 days after hospitalization due to respiratory arrest. A complete necropsy was performed. Histopathologic examination of the lung revealed lipid granuloma, pulmonary leukocytoclastic necrotizing vasculitis of the medium- and large-sized arteries, pulmonary thrombosis, and fibrinoid depositions. This case report describes pulmonary leukocytoclastic necrotizing vasculitis in a dog with Tetralogy of Fallot and peritoneopericardial diaphragmatic hernia. To our knowledge, this is first report of leukocytoclastic necrotizing vasculitis of the pulmonary arteries in uncorrected Tetralogy of Fallot with peritoneopericardial diaphragmatic hernia.

Key words: Hypoxia, Leukocytoclastic vasculitis, Pulmonary necrotizing Vasculitis, Pulmonary vasculitis, Tetralogy of Fallot


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)