Pulmonary Leucocytoclasitc Necrotizing Vasculitis
in a Dog with Uncorrected Tetralogy of Fallot and
Peritoneopericardial Diaphragmatic Hernia
Hyun-Ah Park1, Min-Hee Kang1,
Dae-Young Kim2 and Hee-Myung Park1*
1Department
of Veterinary Internal Medicine, College of Veterinary Medicine,
Konkuk University, Seoul 143-701, South Korea; 2Veterinary
Medical Diagnostic Laboratory, College of Veterinary Medicine,
University of Missouri, Columbia, MO 65211, USA;
*Corresponding author: parkhee@konkuk.ac.kr
Abstract
A 5-year-old, 5.4 kg, intact female mixed-breed
dog presented with acute respiratory distress. Echocardiography showed pulmonary
valvular stenosis with narrowing valvular annulus, ventricular septal defect,
overriding aorta and the right ventricular hypertrophy. Other concurrent
abnormality included sternal deformity, peritoneopericardial diaphragmatic
hernia. The dog was diagnosed as a Tetralogy of Fallot. Despite treatments, the
dog died 4 days after hospitalization due to respiratory arrest. A complete
necropsy was performed. Histopathologic examination of the lung revealed lipid
granuloma, pulmonary leukocytoclastic necrotizing vasculitis of the medium- and
large-sized arteries, pulmonary thrombosis, and fibrinoid depositions. This case
report describes pulmonary leukocytoclastic necrotizing vasculitis in a dog with
Tetralogy of Fallot and peritoneopericardial diaphragmatic hernia. To our
knowledge, this is first report of leukocytoclastic necrotizing vasculitis of
the pulmonary arteries in uncorrected Tetralogy of Fallot with
peritoneopericardial diaphragmatic hernia.