Clinicopathology of Gout in Growing Layers
Induced by Avian Nephrotrophic Strains of Infectious Bronchitis
Virus
Ping Liu§,Guangfu Deng§, XiaoQuan Guo*, Jun Kuang, Caiying
Zhang, Huabin Cao and Guoliang Hu
Clinical Veterinary
Laboratory, Institute of Animal Population Health, College of Animal
Science and Technology, JiangXi Agriculture University, N.O. 1101,
Zhimin Avenue, Nanchang Economic and Technological Development
District Nanchang 330045, P.R. China
*Corresponding author: xqguo20720@aliyun.com
Abstract
To evaluate the effect of avian nephrotrophic
strains of infectious bronchitis virus (IBV) on serum electrolytes, liver and
renal function indexes in growing chickens of a layer strain. 120 healthy
chickens (35 days old) were randomly divided into 2 groups (virus and control),
each group with 60 chickens. The chickens in the virus group and the control
group were challenged by 0.2mL artificial nasal drip with virus and sterile
saline solution per chicken, respectively. Blood parameters of chicken were
evaluated on the 8th, 15th and 22nd day after
challenge, respectively. The results showed that Ca, P, K values in the virus
group were statistically (P<0.001) lower than in the control group on the 22nd
day; Mg values in the control group were statistically (P<0.05) higher than in
the viruses group on the 15th day. UA and CR values in the control
group were significantly lower than in the virus group (UA, P<0.001; CR, P<0.05)
on the 15th day. BUN values in the control group were significantly
higher than in the virus group on the 22nd day. TP, ALB, GLB and GGT
activity in the virus group were significantly higher than in the control group
on the 15th day. Our results demonstrated that chickens infected with
nephrotrophic strains of IBV can cause liver and kidney damage and the results
also provided some evidence for avian visceral gout diagnosis.