Gastrointestinal helminths (GI helminths) are of utmost importance in camels affecting their working potential and productivity. This study was aimed to monitor the status of GI helminths in camels of Cholistan region. This accompanied evaluation of effects exerted by helminthosis on various hematological parameters and comparative therapeutic trails of albendazole and Neem (Azadirachta indica) leaves against GI helminths in camels. A total of 384 camels were randomly selected in this study. The presence of helminths ova was observed using direct smear method, sedimentation and flotation techniques. An overall prevalence of GI helminths was recorded 66.67% in the study area. Trematodes were found the most prevalent parasite’s type followed by nematodes and cestodes. Animals in age range of >10 years were significantly (P<0.05) affected more with nematodes than younger animals (5-10years age). A non-significant (P>0.05) difference in the prevalence between Berella and Marrecha breeds of camel was observed except for the trematodes where Marrecha breed was affected more (34.67%) than the Berella breed (25.16%), (P<0.05). Hemonchus spp. were the most prevalent compared to other nematodes (P<0.05), a non-significant difference was seen in the prevalence among Fasciola gigantica (F. gigantica) and Fasciola hepatica (F. hepatica), (P>0.05). The only cestode found in this study was Monieza expansa (M. expansa). The hematological study found a significant decrease in values of packed cell volume (PCV %), total erythrocyte count (TEC), hemoglobin (Hb) and increased in values of total leukocyte count (TLC), (P<0.05). The therapeutic trial conducted revealed albendazole as a superior drug over Neem leaves in control of GI helminths in camels; however, Neem leaves proved to be a successful candidate as an alternative to albendazole.