Cadmium Toxicity in Female Japanese quail (Coturnix
japonica) and Its Diminution with Silymarin
Salman Latif Butt1, Muhammad Kashif
Saleemi1,*, Muhammad Zargham Khan1, Ahrar Khan1,2,
Muhammad Farooq3, Aisha Khatoon1, Sheraz Ahmad
Bhatti4, Muhammad Waseem Tahir5,
Najam-ul-Islam5, Huma Jamil1 and Faqir
Muhammad1
1Faculty
of Veterinary Science, University of Agriculture, Faisalabad-38040,
Pakistan; 2Shandong Vocational Animal Science and
Veterinary College, 88 Eastern Shengli Street,
Weifang 261061,China; 3Department
of Bioinformatics and Biotechnology, Government College University
Faisalabad, Pakistan; 4Department of Pathobiology,
Faculty of Veterinary Sciences, Bahauddin Zakariya University
Multan, Pakistan; 5Livestock and Dairy Development
Department, Government of Punjab Pakistan *Corresponding author: drkashif313@gmail.com
Abstract
Present study was designed to investigate the
toxico-pathological effects of cadmium in female Japanese quail (Coturnix
japonica) and their attenuation by silymarin. A total of 120 quail chicks of four
weeks of age were assigned into six groups and given basal feed, Cd1
(150 mg.kg−1 feed), Cd2 (300 mg.kg−1 feed) and
SL (250 mg.kg−1 feed) alone and in combinations for 60 days.
Hematological parameters, serum biochemical profile, feed intake, bodyweights,
relative organ weights, egg production and histopathological alterations in
kidney and oviduct were noted. Our results showed dose dependent decrease in
mean relative weight of oviduct but increase in liver, intestine, kidney and
spleen in groups treated with Cd only. Feed intake was decreased in Cd groups
compared with control and bodyweight of Cd treated groups was lower as compared
with control and SL groups. The Hb and PCV values were low but higher values of
blood urea, creatinine, and serum activity of AST and ALT were observed in Cd
treated groups only. Reduced height of mucosal folds collapsed tubular glands,
nuclear degenerative changes and infiltration of plasma cells in parenchymatous
tissue of oviduct were observed in Cd treated groups only. Moreover, Cd exposure
resulted into hemorrhage, casts in tubules, infiltration of mononuclear cells,
tubular necrosis and fibrosis in kidneys. Egg production was also lower in Cd
treated groups as compared with control group.It may be concluded that Cd has strong nephrotoxic and gonadotoxic
effects and SL may effectively ameliorate these toxic effects completely at
lower doses but partially at higher doses of Cd.
To Cite This Article:
Butt SL, Saleemi MK, Khan MZ, Khan A, Farooq M,
Khatoon A, Bhatti SA, Tahir MW, Islam NU, Jamil H and Muhammad F, 2018. Cadmium
toxicity in female Japanese quail (Coturnix
japonica) and its diminution with silymarin. Pak Vet J, 38(3): 249-255.
http://dx.doi.org/10.29261/pakvetj/2018.062