Zinc
Oxide Nanoparticles Effect on Oxidative Status, Brain Activity,
Anxiety-Like Behavior and Memory in Adult and Aged Male Rats
Mona H Hafez
and Shereen B Gad
Department of Physiology, Faculty of Veterinary Medicine, Alexandria
University, P.O. Box 22758, Edfina, Egypt
*Corresponding author:
monahafez2003@yahoo.com; mona.hafez@alexu.edu.eg
Abstract
Zinc is participating in different physiological
processes and it is a functional or structural constituent of many proteins. As
many pieces of evidence point to that in
the elderly the zinc brain homeostasis is affected. The current work studied the
zinc oxide nanoparticles (ZnO NPs) effect on the oxidative status and brain
activity in adult and aged Sprague-Dawley rat brain. Forty male Sprague-Dawley
rats (6 months and 24 months old rats) were used in this study; 10 of each age
category served as a control and 10 rats
of 6 and 24 months old rats were treated with zinc oxide nanoparticles (ZnO NPs)
orally. Morris water maze and elevated plus maze
performance tests were used for neurophysiological evaluations of memory and
anxiety-like behavior, respectively. Brain malondialdehyde (MDA), reduced
Glutathione (GSH) levels, glutathione peroxidase (GPx), superoxide dismutase
(SOD) activities, serum and brain zinc and nitrite contents and creatine kinase (CK), acetylcholine esterase (AChE),
and lactate dehydrogenase (LDH) activities were estimated. Control aged rats
revealed high level of memory impairment, anxiety and oxidative stress damage
which were not found in the control adult rats. ZnO NPs treatment significantly
ameliorated the aging-induced cognitive impairment,
anxiety and oxidative stress damage. The
findings of the present study indicate a protective effect of ZnO NPs against
aging-induced cognitive impairment, anxiety and associated oxidative damage
recommending the use of ZnO NPs for boosting brain function and protecting the
brain from further decay.
To Cite This Article:
Hafez MH and Gad SB, 2018. Zinc
oxide nanoparticles effect on oxidative status, brain activity, anxiety-like
behavior and memory in adult and aged male rats. Pak Vet J, 38(3):
311-315. http://dx.doi.org/10.29261/pakvetj/2018.069