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Effect of Flavonoids from Eupatorium odoratum L. on Immunoglobulins and Cecal Microflora in Broilers
Qiao-Hui Zhang, Fang-Hong Nie, Xiao-Ning Wang1, Hong-Ying Lin1, Hwa-Chain Robert Wang3, Ravi Gooneratne4* and Jin-Jun Chen1*
1Department of Veterinary Medicine, College of Agricultural Sciences; 2Department of Food Safety, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong 524088, China; 3Department of Biomedical and Diagnostic Sciences, The College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA; 4Department of Wine, Food and Molecular Biosciences, Faculty of Agriculture and Life Sciences, Lincoln University, Lincoln 7647, New Zealand; *Corresponding author: (JJC); (RG)


The effects of total flavonoids from Eupatorium odoratum L. (TFEO) on serum (IgM, IgG) and duodenal mucosa (Secretory IgA–SIgA) immunoglobulins and cecal microflora composition in broiler chicken were investigated. Test groups received diets supplemented with 100, 200, or 400 mg/kg TFEO for 21 and 42d. At 21d, IgM levels were higher in the 200 and 400 mg/kg groups compared to control group. IgG and SIgA levels were increased in all test groups (P<0.05). At 42d, IgG content in all test groups were higher (P<0.05), IgM in all test groups was higher (P>0.05). SIgA in all test groups increased at 200 and 400 mg/kg (P<0.01) >100 mg/kg (P<0.05) compared to the controls. Significant increases (P<0.05) in Firmicutes phylum and Bifidobacterium, Lactobacillus and Lachnospira genera gut microbes and significant decreases in pathogenic Escherichia and Clostridium of the test groups were observed at 21 and/or 42d. TFEO flavonoids are suggested for use as a feed additive for broilers to improve cecal microflora and humoral immunity.

To Cite This Article: Zhang QH, Nie FH, Wang XN, Lin HY, Wang HCR, Gooneratne R and Chen JJ, 2018. Effect of flavonoids from Eupatorium odoratum L. on immunoglobulins and cecal microflora in broilers. Pak Vet J, 38(3): 296-300.  


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)