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Effect of Immunomodulator “Immunobeta” on Humoral Innate and Acquired Immune Response in Layer Hens
Nadya Bozakova1, Lilyan Sotirov2*, Tsvetoslav Koynarski2 and Dimitrina Gundasheva3
1Trakia University, Faculty of Veterinary Medicine, Dept. Animal Hygiene, Ethology and Animal Protection, 6000 Stara Zagora, Bulgaria; 2Department of Animal Genetics; 3Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria
*Corresponding author:


The effect of immunomodulator “Immunobeta” was investigated on 6750 layers hybrid Loman Brown divided in two equal groups – control and experimental. The layers were housed in enriched cages constructed in large battery for 3375 hens – one for each group. The experiment started when hens were at 18 weeks of age. The control hens received the usual diet for their age, whereas the experimental birds received a diet supplemented with “Immunobeta” at a dosage of 4 kg/tone for 2 months. The first analysis was conducted prior to treatment (Test I), while the second study was done at the end of treatment, i.e. 2 months later (Test II). The evaluation of residual effect of the immunomodulatory substance was checked one month after the end of treatment (Test III). Twelve hens from each group were analysed in each test. The results indicated that “Immunobeta” increased lysozyme concentration in blood sera and hens’ egg white. It was found that “Immunobeta” elevated the activity of alternative pathway of complement activation and increase the concentration of IgM as well.

To Cite This Article: Bozakova N, Sotirov L, Koynarski T and Gundasheva D, 2018. Effect of immunomodulator “Immunobeta” on humoral innate and acquired immune response in layer hens. Pak Vet J, 38(4): 438-441.  


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)