Effect of Immunomodulator “Immunobeta” on Humoral
Innate and Acquired Immune Response in Layer Hens
Nadya Bozakova1, Lilyan Sotirov2*,
Tsvetoslav Koynarski2 and Dimitrina Gundasheva3
1Trakia
University, Faculty of Veterinary Medicine, Dept. Animal Hygiene,
Ethology and Animal Protection, 6000 Stara Zagora, Bulgaria; 2Department
of Animal Genetics; 3Department of General and Clinical
Pathology, Faculty of Veterinary Medicine, Trakia University, 6000
Stara Zagora, Bulgaria *Corresponding author: sotirov54@gmail.com
Abstract
The effect of immunomodulator “Immunobeta” was
investigated on 6750 layers hybrid Loman Brown divided in two equal groups –
control and experimental. The layers were housed in enriched cages constructed
in large battery for 3375 hens – one for each group. The experiment started when
hens were at 18 weeks of age. The control hens received the usual diet for their
age, whereas the experimental birds received a diet supplemented with “Immunobeta”
at a dosage of 4 kg/tone for 2 months. The first analysis was conducted prior to
treatment (Test I), while the second study was done at the end of treatment,
i.e. 2 months later (Test II). The evaluation of residual effect of the
immunomodulatory substance was checked one month after the end of treatment
(Test III). Twelve hens from each group were analysed in each test. The results
indicated that “Immunobeta” increased lysozyme concentration in blood sera and
hens’ egg white. It was found that “Immunobeta” elevated the activity of
alternative pathway of complement activation and increase the concentration of
IgM as well.
To Cite This Article: Bozakova N, Sotirov L, Koynarski T and Gundasheva
D, 2018. Effect of immunomodulator “Immunobeta” on humoral innate and acquired
immune response in layer hens. Pak Vet J, 38(4): 438-441. http://dx.doi.org/10.29261/pakvetj/2018.070