PAKISTAN VETERINARY JOURNAL

Pak Vet J, 2022, 42(1): 107-111

Ameliorating Effect of Lycopene and N-Acetylcysteine against Cisplatin-Induced Cardiac Injury in Rats

Asmaa Elsayed¹, Ashraf Elkomy¹, Mohamed Alkafafy², Reda Elkammar³, Sabreen Ezzat Fadl⁴, Ehab Yahya Abdelhiee⁵, Ahmed Abdeen⁶, Gehan Youssef⁶, Hassan Shaheen⁷, Ahmed Soliman⁸ and Mohamed Aboubakr¹*

¹Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt; ²Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
³Department of Histology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt; ⁴Biochemistry Department, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt
⁵Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt
⁶Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt; ⁷atco Pharma for Pharmaceutical Industry, Industrial Quisna Zone, ElMenofia, Egypt; ⁸Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, 12211 Giza, Egypt
*Corresponding author: mohamed.aboubakr@fvtm.bu.edu.eg

Abstract

Cisplatin (CP) is one of antineoplastic agents with a broad range of anticancer activities. This research investigated the possible protective effects of lycopene (LP) and N acetylcysteine (NAC) in rats against CP-induced cardiac toxicity. Seven groups of rats (n=7); control vehicle group was administered saline, LP (10 mg/kg, PO), NAC (150 mg/kg, PO), CP group (7.5 mg/kg, IP) on the 27^th day of the experiment, LP-CP group, NAC-CP group, and LP-NAC-CP group. Following injection of CP, concentrations of cardiac biomarkers, lactate dehydrogenase (LDH), creatine kinase (CK) and creatine kinase MB (CK-MB) were increased in serum of the treated groups. In addition, CP resulted in a significant increase in malondialdehyde (MDA), as well as significant decreases in glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) in rats' heart tissues. CP resulted in changes in cardiac histopathology and increased caspase-3 expression in cardiac tissues. Administration of LP and/or NAC ameliorated cardiac toxicity and apoptosis induced by CP, through their antioxidant properties.

To Cite This Article: Elsayed A, Elkomy A, Alkafafy M, Elkammar R, Fadl SE, Abdelhiee EY, Abdeen A, Shaheen H, Soliman A and Aboubakr M, 2022. Ameliorating effect of lycopene and N-acetylcysteine against cisplatin-induced cardiac injury in rats. Pak Vet J, 42(1): 107-111. http://dx.doi.org/10.29261/pakvetj/2021.035

Abstract

ISSN 0253-8318 (Print)ISSN 2074-7764 (Online)

ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)