Ameliorative Effects of Ulva rigida (C. Agardh, 1823) on
Cadmium-induced Nephrotoxicity in Wistar Albino Rats
Latife Ceyda Irkin1*
and Şamil Öztürk2
1Çanakkale
Onsekiz Mart University, Faculty of Applied Sciences, Department of
Fisheries Technology, Çanakkale-Turkey; 2Çanakkale
Onsekiz Mart University, Vocational School of Health Services,
Çanakkale-Turkey
*Corresponding author:
latifeirkin@gmail.com
Abstract
Many organs and systems, especially the kidney,
are damaged by the effect of high-dose cadmium. These functional problems vary
depending on the distribution of cadmium in the body, the way it is taken, the
dose and the duration.
Antioxidant activities of algae are due to the polyphenols, polysaccharides,
pigments and vitamins they contain. Antioxidants
are effective in protecting the body against damage caused by reactive oxygen
species. This study was carried out to determine the therapeutic effects of
Ulva rigida extract on kidney tissue fibrosis, inflammatory inflammation and
apoptosis in cadmium-induced rats. In the study, 1 mg/kg CdCl2 was
injected subcutaneously to the subjects four times a week for one month (G2).
Concurrently, 50 mg/kg (G3) and 100 mg/kg (G4) algae extract were given to the
subjects by gavage. In staining with hematoxylin-eosin, mononuclear cell
infiltration in the kidney tissues, dilatation in the tubules, shrinkage of the
glomeruli and degeneration of epithelium occurred with the induction of Cd.
Immunohistochemically, it was determined that TGF-β, TNF-α and NF-kB
immunoreactivity was high due to tubular cells undergoing inflammation and
apoptosis. Histopathological data show that U. rigida extract has a
protective role against kidney damage in Cd-induced rats.Algae extract was
found to play a protective role against cadmium-induced kidney damage. It was
also found to have an important role as a therapeutic agent against oxidative
stress.
To Cite This Article:
Irkin LC and Öztürk Ş, 2022.
Ameliorative effects of Ulva rigida (C. Agardh, 1823) on cadmium-induced
nephrotoxicity in Wistar albino rats.
Pak Vet J, 42(3): 419-423.
http://dx.doi.org/10.29261/pakvetj/2022.051