PAKISTAN
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Effects of Maternal Undernutrition on Coronary Vasculature of Fetuses and Neonates in Rabbits (Oryctolagus cuniculus)
 
Sarmad Rehan1*, Anas Sarwar Qureshi1, Razia Kausar1 and Muhammad Kashif Saleemi2
 

1Department of Anatomy, Faculty of Veterinary Science, University of Agriculture, Faisalabad
2Department of Pathology, Faculty of Veterinary Science, University of Agriculture, Faisalabad
*Corresponding author: drsarmadpk@gmail.com

Abstract   

This experiment was designed to determine the maternal under-nutritional effects on coronary vessels in rabbit fetuses. Forty healthy pregnant female, adult rabbits (does) were divided into two groups, well-nourished (WN) and under-nourished (UN). Five pregnant does from each group were euthanized after specific time intervals (two week, three weeks, four weeks and after parturition). Fetuses were recovered and fetal hearts fixed in 10 percent neutral buffered formalin solution, then subjected to paraffin tissue preparation technique. The cross-section images of the coronary vessels were analyzed with image analysis software ImageJ®. The lowest mean (9.96±1.34 um) coronary intima media thickness (IMT) was found in WN fetuses (2nd week) and highest in UN neonates (46.14±1.50 um). The lowest mean coronary vessel luminal diameter was found in UN fetuses at 2nd week of development (25.52±6.48 um) and highest in WN neonates (120.31±22.31 um). The lowest mean coronary vessel luminal diameter was found in WN fetuses at 2nd week of development (24.88±6.45 um) and highest in UN neonates (120.31± 22.31 um). The lowest mean coronary vascular diameter was observed in WN fetuses at 2nd week (39.06± 12.84 um), highest in WN neonates (146.27± 14.84 um). The lowest mean coronary vascular perimeter was found in UN fetuses at 2nd week of development (122.7± 46.60 um) and highest in UN neonates (458.1± 46.63 um). Thus, maternal undernutrition and developmental age increased coronary IMT, however, other parameters decreased with maternal undernutrition and increased with age of fetuses.

To Cite This Article: Rehan S, Qureshi AS, Kausar R, Saleemi MK, 2022. Effects of maternal undernutrition on coronary vasculature of fetuses and neonates in rabbits (Oryctolagus cuniculus). Pak Vet J. http://dx.doi.org/10.29261/pakvetj/2022.090

 
   
 

ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)



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